Improving the Performance of a 3-Stage Cyclic Crystallization Process Using a Hydrocyclone

A dissolution process featuring a hydrocyclone for the selective removal of fine crystals, i.e., an operation analyzed through modeling and experiments in earlier studies, is implemented into 3-stage cyclic crystallization process, which consists repeated application crystal growth, wet milling, dissolution. For selection its operating conditions, demonstrate that mathematical model provides accurate estimates classification curve different compounds physical properties suspension, thus facilitating design. Two campaigns are conducted with two compounds, namely, γ d-mannitol β l-glutamic acid, where strategy compared to standard partial terms attributes final product powder obtained from process. Crystal size, shape, flowability, filterability measured, it shown they greatly influenced by stages. Most remarkably, case d-mannitol, experimental evidence shows enables greater amount fines same mass crystals being dissolved, improving productivity as well measured flow filtration performance.